PPI Dose Conversion & Switching Guide

Proton pump inhibitors are similar in efficacy at equivalent doses, but differ in drug interactions and metabolism. Use this chart to convert between PPIs and review clinically relevant differences.

Dose Equivalency Guide

Approximate equivalent doses within Proton Pump Inhibitors

Drug	Low Dose	Medium Dose	High Dose	Notes
omeprazole	10 mg	20 mg	40 mg	OTC available; take 30-60min before meals
esomeprazole	10 mg	20 mg	40 mg	S-isomer of omeprazole; similar efficacy
lansoprazole	15 mg	30 mg	30 mg BID	OTC available
pantoprazole	20 mg	40 mg	40 mg BID	Fewest drug interactions of PPIs
rabeprazole	10 mg	20 mg	20 mg BID	Fastest onset of action
dexlansoprazole	30 mg	30 mg	60 mg	Dual-release; can be taken without regard to food

Source: AGA Clinical Practice Guidelines

Individual Drug Pages

Omeprazole Esomeprazole Lansoprazole Pantoprazole Rabeprazole Dexlansoprazole