Omeprazole
Also sold as: Yosprala, Prilosec, Talicia, Konvomep, Zegerid Reformulated Aug 2006 (+1 more)
Dose Equivalency Guide
Approximate equivalent doses within Proton Pump Inhibitors
| Drug | Low Dose | Medium Dose | High Dose | Notes |
|---|---|---|---|---|
| omeprazole (this drug) | 10 mg | 20 mg | 40 mg | OTC available; take 30-60min before meals |
| esomeprazole | 10 mg | 20 mg | 40 mg | S-isomer of omeprazole; similar efficacy |
| lansoprazole | 15 mg | 30 mg | 30 mg BID | OTC available |
| pantoprazole | 20 mg | 40 mg | 40 mg BID | Fewest drug interactions of PPIs |
| rabeprazole | 10 mg | 20 mg | 20 mg BID | Fastest onset of action |
| dexlansoprazole | 30 mg | 30 mg | 60 mg | Dual-release; can be taken without regard to food |
Source: AGA Clinical Practice Guidelines
Related Medications
These drugs share a pharmacologic classification but are NOT interchangeable. Listing here does not imply clinical equivalence. A physician must evaluate each drug individually for the patient's specific condition.
Classification: Proton Pump Inhibitors (source: RxClass/NLM)
Insurance Coverage User-Reported
No community coverage data yet for omeprazole.
Coverage data submission coming soon.
Drug Information
Indications & Uses
Use(s) treats frequent heartburn (occurs 2 or more days a week) not intended for immediate relief of heartburn; this drug may take 1 to 4 days for full effect
Dosage & Administration
Directions for adults 18 years of age and older this product is to be used once a day (every 24 hours), every day for 14 days it may take 1 to 4 days for full effect; some people get complete relief of symptoms within 24 hours 14-Day Course of Treatment swallow 1 tablet with a glass of water before eating in the morning take every day for 14 days do not take more than 1 tablet a day do not use for more than 14 days unless directed by your doctor swallow whole. Do not chew or crush tablets Repeated 14-Day Courses (if needed) you may repeat a 14-day course every 4 months do not take for more than 14 days or more often than every 4 months unless directed by a doctor children under 18 years of age: ask a doctor. Heartburn in children may sometimes be caused by a serious condition.
Warnings & Precautions
Warnings Allergy alert: do not use if you are allergic to omeprazole omeprazole may cause severe skin reactions. Symptoms may include: skin reddening blisters rash If an allergic reaction occurs, stop use and seek medical help right away. Do not use if you have: trouble or pain swallowing food, vomiting with blood, or bloody or black stools heartburn with lightheadedness, sweating or dizziness chest pain or shoulder pain with shortness of breath; sweating; pain spreading to arms, neck or shoulders; or lightheadednes frequent chest pain These may be signs of a serious condition. See your doctor. Ask a doctor before use if you have : had heartburn over 3 months. This may be a sign of a more serious condition. frequent wheezing, particularly with heartburn unexplained weight loss nausea or vomiting stomach pain Ask a doctor or pharmacist before use if you are taking a prescription drug. Acid reducers may interact with certain prescription drugs. Stop use and ask doctor if: your heartburn continues or worsens you need to take this product for more than 14 days you need to take more than 1 course of treatment every 4 months you get diarrhea you develop a rash or joint pain If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222)
Verify with Primary Sources
Always verify clinical information with authoritative sources.
Medical Disclaimer: Information on this page is sourced from FDA-approved labeling data and is for educational reference only. It does not constitute medical advice. This information does not establish a provider-patient relationship. Always verify with current prescribing information and consult a licensed healthcare professional before any clinical decision. Read full disclaimer.
Data sourced from RxNorm (NLM/NIH), FDA Orange Book, OpenFDA, DailyMed. Last updated: 2026-03-02.