ARB Switching & Dose Conversion Guide

ARBs are commonly switched when patients need different potency or have specific comorbidities. This guide covers equivalent doses and clinically relevant differences between ARBs.

Dose Equivalency Guide

Approximate equivalent doses within Angiotensin Receptor Blockers

Drug	Low Dose	Medium Dose	High Dose	Notes
losartan	25-50 mg daily	50-100 mg daily	100 mg	Only ARB with uricosuric effect (helps gout)
valsartan	40-80 mg daily	80-160 mg daily	320 mg	Strong HF data (Val-HeFT); no prodrug conversion needed
irbesartan	75-150 mg daily	150-300 mg daily	300 mg	Good diabetic nephropathy data
candesartan	4-8 mg daily	8-16 mg daily	32 mg	Longest acting; strong HF data
olmesartan	10-20 mg daily	20-40 mg daily	40 mg	FDA warning: sprue-like enteropathy (rare)
telmisartan	20-40 mg daily	40-80 mg daily	80 mg	Longest half-life; partial PPAR-gamma agonist
azilsartan	40 mg daily	80 mg daily	80 mg	May have superior BP lowering; newest ARB

Source: Standard pharmacology references

Individual Drug Pages

Losartan Valsartan Irbesartan Candesartan Olmesartan Telmisartan Azilsartan