ACE Inhibitor Switching & Dose Conversion Guide
ACE inhibitors are largely interchangeable within the class. This guide covers dose equivalency, key pharmacologic differences, and practical tips for switching between ACE inhibitors.
Dose Equivalency Guide
Approximate equivalent doses within ACE Inhibitors
| Drug | Low Dose | Medium Dose | High Dose | Notes |
|---|---|---|---|---|
| lisinopril | 5-10 mg daily | 20-40 mg daily | 80 mg | Once daily; most prescribed ACE inhibitor |
| enalapril | 2.5-5 mg BID | 10-20 mg BID | 40 mg/day | Twice daily dosing |
| ramipril | 1.25-2.5 mg daily | 10 mg daily | 20 mg | Strong cardiovascular outcome data (HOPE trial) |
| benazepril | 5-10 mg daily | 20-40 mg daily | 80 mg | Once or twice daily |
| captopril | 12.5 mg TID | 25-50 mg TID | 450 mg/day | Three times daily; shortest acting |
| quinapril | 5-10 mg daily | 20-40 mg daily | 80 mg | Once or twice daily |
| fosinopril | 5-10 mg daily | 20-40 mg daily | 80 mg | Dual hepatic/renal clearance — good for CKD |
Source: Standard pharmacology references
Individual Drug Pages
Medical Disclaimer: Dose equivalency data is approximate and intended for educational reference only. Always verify with current prescribing information and consult a licensed healthcare professional before making any clinical decision. Read full disclaimer.