What drug class is trifluridine?

trifluridine is classified as a Nucleic Acid Synthesis Inhibitors.

Is there a generic version of trifluridine?

Yes, generic versions of trifluridine are available. See the Exact Equivalents section above for FDA-rated generic alternatives.

How does trifluridine work?

trifluridine mechanism of action information is available in the Drug Information section of this page.

Trifluridine

Also sold as: Lonsurf, Viroptic

Nucleic Acid Synthesis InhibitorsPrescription OnlyGeneric Available

Related Medications

Important: Only drugs listed as "Exact Equivalents" (FDA AB-rated) are confirmed interchangeable. All other listings are for informational reference only and do NOT indicate that drugs can be substituted without a physician's explicit guidance.

Same Pharmacologic Class

These drugs share a pharmacologic classification but are NOT interchangeable. Listing here does not imply clinical equivalence. A physician must evaluate each drug individually for the patient's specific condition.

Classification: Nucleic Acid Synthesis Inhibitors (source: RxClass/NLM)

Insurance Coverage User-Reported

Community Data Disclaimer: Insurance coverage information below was submitted by RxSaurus users and has not been verified by RxSaurus. Coverage varies by plan, year, geography, and individual circumstances. Drug formulary status, prior authorization requirements, and tier placements change frequently. Always verify coverage directly with the patient's insurance plan or pharmacy benefits manager before prescribing or dispensing.

No community coverage data yet for trifluridine.

Coverage data submission coming soon.

Drug Information

Indications & Uses

INDICATIONS AND USAGE: Trifluridine Ophthalmic Solution is indicated for the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus, types 1 and 2.

Dosage & Administration

DOSAGE AND ADMINISTRATION: Instill one drop of Trifluridine Ophthalmic Solution onto the cornea of the affected eye every 2 hours while awake for a maximum daily dosage of nine drops until the cornea ulcer has completely re-epithelialized. Following re-epithelialization, treatment for an additional 7 days of one drop every 4 hours while awake for a minimum daily dosage of five drops is recommended. If there are no signs of improvement after 7 days of therapy or complete re-epithelialization has not occurred after 14 days of therapy, other forms of therapy should be considered. Continuous administration of trifluridine for periods exceeding 21 days should be avoided because of potential ocular toxicity.

Warnings & Precautions

WARNINGS: The recommended dosage and frequency of administration should not be exceeded (See DOSAGE AND ADMINISTRATION ).

Side Effects (Adverse Reactions)

ADVERSE REACTIONS: The most frequent adverse reactions reported during controlled clinical trials were mild, transient burning or stinging upon instillation (4.6%) and palpebral edema (2.8%). Other adverse reactions in decreasing order of reported frequency were superficial punctate keratopathy, epithelial keratopathy, hypersensitivity reaction, stromal edema, irritation, keratitis sicca, hyperemia, and increased intraocular pressure.

Contraindications

CONTRAINDICATIONS: Trifluridine Ophthalmic Solution is contraindicated for patients who develop hypersensitivity reactions or chemical intolerance to trifluridine.

Verify with Primary Sources

Always verify clinical information with authoritative sources.

DailyMed (NLM/NIH)FDA-approved drug labeling↗FDA Orange BookTherapeutic equivalence data↗RxNorm (NLM/NIH)Drug nomenclature & relationships↗